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Shreis-Scalene Sciences LLC
11516 Darnestown Rd. Gaithersburg,MD 20878

Tel : (001)301-926-0566
Fax : (001)301-926-2925

email : Shré


Frequently asked Questions

What is Realistic Geometry Cartographic Imaging?

The new field of Realistic Geometry Cartographic Imaging (RGCI) finds application in the field of Science, Technology, Oil Exploration, Nuclear Science, Medical Imaging etc,. RGCI is a patent pending imaging technique, where, in simple terms, the structure of an object is imaged based on the behavior of the object.

How is RGCI applied in Imaging Coronary Artery Stenosis?

The parameters needed for RGCI are first acquired. The acquired parameters are then mapped against a mathematical model and a cartogram is obtained, which is the collective behavioral pattern of the Heart and its Circulation status. The deviation difference of these behavioral patterns are then calculated and a three dimensional array of image units are created which is embedded in to a realistic geometry model of the structure of the coronaries. These images are called Realistic Geometry Cartographic Images (RGCI)..

What are the parameters needed for RGC Imaging of Coronary Artery Disease. ?

Since the Human Cardiovascular system is a closed loop fluid mechanics system, we will need all the parameters relating to Pressure, Volume and Time to obtain the true behavior of the system.

 How are such complex parameters obtained non-invasively?

All these complex parameters are obtained using high precision data acquisition system. Pressure, Volume, Time are collectively obtained by simultaneously recorded Electrocardiography, Vertical acceleration detection (VAD) of heart sounds, non-invasive continuous blood pressure, trans-aortic signal wave modulation (TASWM) and Turbulent Flow Accelerometry (TFA).

How are the measurement made on the patients?

The patient is first wired to the ssscyto using 12 disposable electrode (4 for ECG and 8 for TASWM and a special high sensitive narrow bandwidth VAD. The recording is made for about 5 minutes at rest in the supine position. A high-speed computer with parallel processing architecture computes the algorithms and prints out the results.  

How long does the whole procedure take?

The whole procedure takes about 20 minutes, from start to finish.  

What do I get as a result?

You get the data that was never possible earlier by non-invasive methods. You get the complete cardiac haemodynamics including beat-to-beat stroke volume, all systolic and diastolic time intervals, pressure, volume and Time relationship, relative myocardial oxygen demand, supply and coronary reserve, diastolic filling patterns, preload, afterload, contractility and left ventricular ejection rate. All these parameters give the patient's complete cardiac status.

What about the Images ?

Images include the cardiovascular cartography, which signifies the pressure, volume and time relationship. The realistic geometry  view of the coronaries, that indicate the location and severity of coronary artery disease and the relative myocardial oxygen demand, supply and reserve curves.

How accurate is the RGC imaging when compared to coronary angiography studies ?

The last reported study shows that RGC imaging has a positive predictive accuracy of 98.28% and a negative predictive accuracy of 82.16% in detecting coronary artery disease. And a sensitivity and specificity of over 90%, which the experts say is good enough for a non-invasive test.

Up to what level of coronary artery disease can the RGC imaging detect?

RGC Imaging can detect coronary artery stenosis as low as 20 %. Theoretically, RGC Imaging should also detect elastic stenosis that is vulnerable and cannot be seen on coronary angiograms.

What are the other uses of RGC Imaging in my clinical practice?

In cardiology, well! This is the only way to follow neonates during intensive treatment, where invasive techniques are impossible. You can determine the haemodynamic state of your patient when invasive methods cannot be utilized. Trend analysis will help you in determining the proper therapy with the use of selected parameters. You can forecast myocardial ischemia, prior to development of anginal pain. You can optimize AV delay in patients with dual chamber pacemakers and impaired left ventricular function. You can use it during rehabilitation of your post-CABG and post-PTCA patients by determining the actual working point of the heart related to flow and pressure by each measurement, besides reliably detecting Coronary artery disease.

 Has any part of this technique made it to a scientific podium?

Yes. At the 8th European congress of intensive care medicine, Athens, Greece, 1995, 12th International congress " The new Frontiers of Arrhythmias", Italy, 1996. 3rd International conference on Impedance Cardiography, Domdovar, Hungary, 1997. The 4th Asia pacific symposium on electrophysiology, New Delhi, India, 1997. The 50th scientific session of the cardiological society of India, Mumbai, India, 1998. IEEE conference on Computers in Medicine, NIH, Bethesda, MD, USA in July 2001, to name a few.

 Is the RGC Imaging used anywhere ?

The technique is being studied in many parts of Europe and in India there are quite a few Installations that have just started providing RGC imaging services.     The system is now being introduced into the United States, Canada, Mexico and South American countries by Shréis-Scalene Sciences Inc.

 Is there any skepticism about RGC Imaging ?

Yes, there is bound to be skepticism as is normal in any filed of activity.  This is but natural, mainly due to  not looking at the system with an open mind.  A trained physician is needed to interpret the results and  "cardiovascular mapping"  requires a physician who is specially trained to analysis these maps.  Errors can creep in only in the  interpretation. RGC  of thousands of patients studied and the results agreed very well with their coronary angiograms.

 What is cardiovascular mapping?

Cardiovascular mapping was the first step into physiology based diagnosis of coronary artery disease. It was the first generation non-invasive method to determine coronary artery disease, based on cardiac haemodynamic variability. Though the cardiovascular mapping was highly accurate, it needed a trained physician to interpret the map patterns. RGC imaging is straight forward, and does not require a trained physician but a physician familiar with coronary anatomy can interpret the images.

 How expensive is the complete system ?

The complete system 'ssscyto - 256' including the software is extremely low cost compared to some of the systems available in the research and medical field that provide only a fraction of the output that ssscyto - 256 gives.

 How expensive it is to conduct one procedure?

This is where RGC Imaging scores over the other imaging techniques. The cost per procedure is a fraction of the cost for any other cardiac evaluation.

 How do I check if this technique works. ?

  It is very simple, Have the test done on some of your patients who are scheduled for coronary angiography (better with intra vascular ultra-sound), check your angiographic findings with the RGC images. Is this not an Acid Test. ?   

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Shréis-Scalene Sciences Inc is a registered US Company


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